ytdA
168
similar to UTP-glucose-1-phosphate uridylyltransferase
locus
BSU_30850
Molecular weight
30.03 kDa
pI
5.91
function
unknown
product
unknown
essential
no
ec
2.7.7.9
synonyms
ytdA, yzwA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1210 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,154,735 → 3,155,553
The protein
Catalyzed reaction/ biological activity
α-D-glucose 1-phosphate + H+ + UTP --> diphosphate + UDP-α-D-glucose (according to UniProt)
Protein family
UDPGP type 2 family (with [protein|D368988F85D8436DD424B0B4A1591BDF092A8EA7|gtaB] and [protein|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB], according to UniProt)
Structure
[PDB|7B1R] ([protein|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB], 44% identity) [pubmed|33556370]
[PDB|3JUJ] (UDP-glucose pyrophosphorylase from ''Helicobacter pylori'', 43% identity) [Pubmed|20238176]
[AF|P42407]
Paralogous protein(s)
[protein|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB], [protein|D368988F85D8436DD424B0B4A1591BDF092A8EA7|gtaB]
[wiki|Localization]
outer spore coat [Pubmed|26577401]
Expression and Regulation
Operons
genes
[gene|FC455B727F66632D94D93E103B30748944ED04A0|ytdA]
description
[Pubmed|22383849]
regulation
expressed late during [wiki|sporulation] in the mother cell ([wiki|SigK]) [Pubmed|26577401]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Biological materials
Mutant
MGNA-A281 (ytdA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/281 NBRP B. subtilis, Japan]
BKE30850 (Δ[gene|FC455B727F66632D94D93E103B30748944ED04A0|ytdA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGGTATTTTCCCCTCAGC, downstream forward: _UP4_AAGAACCCCCAATAATTGGG
BKK30850 (Δ[gene|FC455B727F66632D94D93E103B30748944ED04A0|ytdA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGGTATTTTCCCCTCAGC, downstream forward: _UP4_AAGAACCCCCAATAATTGGG
References
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Time of last update: 2024-12-27 02:54:40
Author of last update: Jstuelk