polC
168
DNA polymerase III, leading strand polymerase (alpha subunit), part of the [wiki|replisome]
locus
BSU_16580
Molecular weight
162.42 kDa
pI
5.14
function
[category|SW.3.1.1|DNA replication]
product
DNA polymerase III (alpha subunit)
essential
yes
ec
2.7.7.7
synonyms
polC, mutI, dnaF, dnaP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2176 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,727,133 → 1,731,446
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
2'-deoxyribonucleoside 5'-triphosphate + DNA(n) --> diphosphate + DNA(n+1) (according to UniProt)
required for bacteriophage SPP1 replication [Pubmed|23268446]
Protein family
DNA polymerase type-C family (with [protein|48BC0FA9901F174472EB070C539EC75EC7C10E88|yorL] and [protein|65B5EA4DBDF5B260DED754B8A7B226AA88F17B55|dnaE], according to UniProt)
[wiki|Domains]
[wiki|Exonuclease domain] (aa 421-578) (according to UniProt)
Structure
[PDB|3F2B] (from ''Geobacillus kaustophilus'', 71% identity) [Pubmed|19106298]
[AF|P13267]
[wiki|Localization]
forms foci [Pubmed|21958350]
about three molecules of PolC at each replication fork [pubmed|28002733]
Expression and Regulation
Operons
genes
[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
description
[Pubmed|22383849]
genes
[gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
description
[Pubmed|22383849]
additional information
about 60 molecules per cell [pubmed|28002733]
References
Reviews
Original Publications
Page visits: 4882
Time of last update: 2024-10-13 04:47:06
Author of last update: Jstuelk