hxlB
168
6-phospho-3-hexuloisomerase
locus
BSU_03450
Molecular weight
19.82 kDa
pI
5.79
function
ribulose monophosphate pathway for formaldehyde fixation
product
6-phospho-3-hexuloisomerase
essential
no
ec
5.3.1.27
synonyms
hxlB, yckF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0794 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
374,603 → 375,160
The protein
Catalyzed reaction/ biological activity
D-arabino-hex-3-ulose 6-phosphate --> β-D-fructose 6-phosphate (according to UniProt)
Protein family
SIS family (single member, according to UniProt)
[wiki|Domains]
[wiki|SIS domain] (aa 29-172) (according to UniProt)
Structure
[PDB|1M3S] [pubmed|15363790]
[AF|P42404]
Expression and Regulation
Operons
genes
[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]-[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB]
description
[Pubmed|10572115]
regulation
induction by formaldehyde ([protein|search|HxlR]) [Pubmed|10572115]
regulatory mechanism
[protein|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR]: activation, [Pubmed|10572115], in [regulon|protein:D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR regulon]
Biological materials
Mutant
MGNA-C056 (yckF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2054 NBRP B. subtilis, Japan]
BKE03450 (Δ[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTATTCAGTCGTTTTCATCG, downstream forward: _UP4_TAGCATCACACAACCGGCCT
BKK03450 (Δ[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTATTCAGTCGTTTTCATCG, downstream forward: _UP4_TAGCATCACACAACCGGCCT
References
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Time of last update: 2025-04-07 07:11:33
Author of last update: Melvin.boenninger