resA
168
extracytoplasmic thioredoxin, cytochrome c biogenesis, reduces disulfide bonds in apo-cytochrome prior to the attachment of heme
locus
BSU_23150
Molecular weight
20.76 kDa
pI
8.37
function
cytochrome c biogenesis
product
extracytoplasmic thioredoxin
essential
no
synonyms
resA, ypxA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1225 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,420,804 → 2,421,343
Phenotypes of a mutant
essential according to [http://www.ncbi.nlm.nih.gov/pubmed/12682299 Kobayashi et al.], but inactivation of ''resA'' was reported by [http://www.ncbi.nlm.nih.gov/pubmed/12637552 Erlendsson et al.] and by [http://www.ncbi.nlm.nih.gov/pubmed/26735940 Meeske et al. ]
inactivation of ''[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]'' reduces sporulation efficiency to 45.6% that of wild type cells; delayed entry into sporulation [Pubmed|26735940]
The protein
Protein family
[wiki|Thioredoxin family] (according to UniProt)
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 36-174) (according to UniProt)
Structure
[PDB|3C73]
[AF|P35160]
Paralogous protein(s)
[protein|0B299F9459023306FA91298A6162A09E4A87C3B2|stoA], [protein|50BBC8AB77B99B9FE5B8A8FE906D39DFEA4ED652|yneN]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]-[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|22383849]
genes
[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [PubMed|8631715,11222591], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9988472], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|16825793], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8631715], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE23150 (Δ[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23150 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCCACTGCCCCCTTC, downstream forward: _UP4_ATAAAACCCGGAGAGACTTC
BKK23150 (Δ[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23150 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCCACTGCCCCCTTC, downstream forward: _UP4_ATAAAACCCGGAGAGACTTC
References
Reviews
Original Publications
Page visits: 3686
Time of last update: 2025-04-02 20:55:23
Author of last update: Jstuelk