yqaH
168
antagonist of [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA], skin element
locus
BSU_26310
Molecular weight
9.27 kDa
pI
5.69
function
inhibition of [wiki|DNA replication], [wiki|sporulation] and [wiki|biofilm formation]
product
antagonist of [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA]
essential
no
ec
null
synonyms
yqaH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,697,419 → 2,697,676
Phenotypes of a mutant
overexpression of YqaH causes cell filamentation and abnormal chromosome segregation, suggesting that overproduction of these proteins inhibits DNA replication, perhaps due to the interaction with [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA] [Pubmed|20889742]
The protein
Catalyzed reaction/ biological activity
binds to the DNA-binding domain IV of [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA] to inhibit [wiki|DNA replication] [pubmed|36748575]
Structure
[AF|P45905]
[wiki|Localization]
Cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|16BEDCFFB1671793061ACE4AC528D3B8EB177DC8|yqaF]-[gene|02216407B5EDB98FAF611E22B2323C819B9D58BB|yqdA]-[gene|03DAF537379754763646AF3AF2AD811B107F5302|yqaG]-[gene|F6AB74740776179E77218DB831FEE03773B7353F|yqaH]-[gene|5EA0F507F949D249D5B5B860861BBEB4197E01C5|yqaI]-[gene|CFCCFD8C6420CC1DD076B091AD3D914FC8AB22D5|yqaJ]-[gene|903E11BD2CFF3EE1A831F0F50F91741893C3DAB8|yqaK]-[gene|AB4AF9BD3E16FD72370AFC82CDD1531518053E6F|yqaL]-[gene|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|yqaM]-[gene|A9AACF8F25A1A80B3AE2A94DFC3A0E09012B55E7|yqzO]-[gene|3A89444BA25E4940C4197AACBD8B66BC1C65A493|yqaN]
description
[Pubmed|20889742]
regulation
not expressed during normal growth ([protein|846161AE54F170075F2B2133A8D56FE39A5AF8D9|sknR]) [Pubmed|20889742]
regulatory mechanism
[protein|846161AE54F170075F2B2133A8D56FE39A5AF8D9|sknR]: repression, [Pubmed|20889742], in [regulon|protein:846161AE54F170075F2B2133A8D56FE39A5AF8D9|sknR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|20889742], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between [gene|CFCCFD8C6420CC1DD076B091AD3D914FC8AB22D5|yqaJ] and [gene|5EA0F507F949D249D5B5B860861BBEB4197E01C5|yqaI] [PubMed|20525796]
References
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Time of last update: 2024-12-20 21:03:35
Author of last update: Jstuelk