yxdK
168
two-component sensor kinase, regulation of the [wiki|ABC transporter] [protein|8B4267532B9788AEB5EF39E2695C1FDA494C7055|yxdL]-[protein|4423383A3F6DAFDFA210F4BEEF7D8CBEC674DCEA|yxdM] in response to the cationic antimicrobial peptide, LL-37
locus
BSU_39650
Molecular weight
37.83 kDa
pI
6.23
function
resistance against toxic peptides
product
two-component sensor kinase
essential
no
synonyms
yxdK, apeS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0642 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,071,310 → 4,072,287
Phenotypes of a mutant
defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|F3C5505E311E6DDABAFA87899F28CF6596CDBA63|yxdJ]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
two transmembrane segments
[wiki|Histidine kinase domain] (aa 118-325) (according to UniProt)
Structure
[AF|P42422]
Modification
autophosphorylation on a His residue
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|F3C5505E311E6DDABAFA87899F28CF6596CDBA63|yxdJ]-[gene|F5BB96607452AC38ECF66923DB8758C364FE2F46|yxdK]
description
[Pubmed|10746760]
Biological materials
Mutant
MGNA-B804 (yxdK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1803 NBRP B. subtilis, Japan]
BKE39650 (Δ[gene|F5BB96607452AC38ECF66923DB8758C364FE2F46|yxdK]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCATGAGACCGGAGAAACA, downstream forward: _UP4_TAAGGCTGCGTTAAGAAAAC
BKK39650 (Δ[gene|F5BB96607452AC38ECF66923DB8758C364FE2F46|yxdK]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCATGAGACCGGAGAAACA, downstream forward: _UP4_TAAGGCTGCGTTAAGAAAAC
References
Reviews
Original Publications
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Time of last update: 2024-12-20 07:03:29
Author of last update: Jstuelk