mmgC
168
acyl-CoA dehydrogenase
locus
BSU_24150
Molecular weight
40.71 kDa
pI
8.52
function
mother cell metabolism
product
acyl-CoA dehydrogenase
essential
no
synonyms
mmgC, yqiN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1960 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,510,806 → 2,511,945
The protein
Catalyzed reaction/ biological activity
A + 2,3-saturated acyl-CoA --> 2,3-dehydroacyl-CoA + AH2 (according to UniProt)
Protein family
[wiki|Acyl-CoA dehydrogenase family] (according to UniProt)
[wiki|Cofactors]
FAD (according to UniProt)
Structure
[PDB|3OWA] (from ''B. anthracis'', 39% identity, 55% similarity)
[PDB|4L1F] (from ''Acidaminococcus Fermentans'', 56% identity)
[AF|P45857]
Paralogous protein(s)
[protein|6416197EF316D74998012765EF9819072C38D2E2|yotC], [protein|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA], [protein|BA28DFBAF88A4994B0541D1FF2187312FDE1FA15|yngJ]
[protein|B5325CBF1408E2CA227EB462092E209F4C87E797|fadE], Array
Expression and Regulation
Operons
genes
[gene|226100C0AC13BB345DB0F0F309DEB7F91F3770B0|mmgA]-[gene|FB95ABDC8557F26525E8B211595C130A7203ABC0|mmgB]-[gene|F25CDDEBAFC72036664323619F5197D45E86BE9A|mmgC]-[gene|3DB116F7423C31838ED6EE090B94DA5F93A4F40C|mmgD]-[gene|602EAB591A550F68C14F35F6E5F0A91C3B997343|mmgE]-[gene|2F4A025B8E3F14764D24CD7E33F7608C2EB1C42C|mmgF]
description
[Pubmed|8759838]
regulation
expressed early during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|15699190,8759838]
strongly expressed during oligotrophic growth [pubmed|30792386]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|8759838], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,8759838], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Biological materials
Mutant
BKE24150 (Δ[gene|F25CDDEBAFC72036664323619F5197D45E86BE9A|mmgC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24150 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACTCGGCCACCCCCGGAT, downstream forward: _UP4_TGATAGACAAAAAACGCAAA
BKK24150 (Δ[gene|F25CDDEBAFC72036664323619F5197D45E86BE9A|mmgC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24150 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACTCGGCCACCCCCGGAT, downstream forward: _UP4_TGATAGACAAAAAACGCAAA
References
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Time of last update: 2024-10-04 08:41:30
Author of last update: Melvin.boenninger