rpsB
168
ribosomal protein uS2
locus
BSU_16490
Molecular weight
27.00 kDa
pI
6
function
translation
product
ribosomal protein uS2
essential
yes
synonyms
rpsB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0052 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,717,933 1,718,673
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]
The protein
Protein family
universal [wiki|ribosomal protein] uS2 family (single member, according to UniProt)
Structure
[PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
[AF|P21464]
[wiki|Localization]
[wiki|ribosome], at the dimer interface of hibernating ribosomes to prevent loss of the protein [pubmed|32123037]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]
description
[pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, [Pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]
[protein|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]: autorepression, [pubmed|32448158], in [regulon|protein:F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB regulon]
genes
[gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
description
[pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]
Biological materials
lacZ fusion
pGP602 (in [wiki|pAC6]), available in [wiki|Stlke] lab
References
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Time of last update: 2024-12-22 01:43:51
Author of last update: Jstuelk