narK
168
nitrite extrusion protein
locus
BSU_37320
Molecular weight
42.80 kDa
pI
10.1
function
nitrate respiration, nitrite export
product
nitrite extrusion protein
essential
no
synonyms
narK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2223 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,832,327 → 3,833,514
The protein
Protein family
[wiki|major facilitator superfamily] (according to UniProt)
Nitrate/nitrite porter (TC 2.A.1.8) family (with [protein|2DE7BEC614129384779F4C761E0792385DECC563|nasA], according to UniProt)
Structure
[PDB|4JR9] (from E. coli, 25% identity) [pubmed|23665960]
[AF|P46907]
Paralogous protein(s)
[protein|2DE7BEC614129384779F4C761E0792385DECC563|nasA]
[wiki|Localization]
cell membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]-[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]
description
[Pubmed|8846791]
regulation
''[protein|search|fnr]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
regulatory mechanism
[protein|EC6697D5D945B7E5083AFED9218748763C443278|nsrR]: repression, [Pubmed|16885456], in [regulon|protein:EC6697D5D945B7E5083AFED9218748763C443278|nsrR regulon]
[protein|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]: activation, [Pubmed|8846791,16428414], in [regulon|protein:7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8846791], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE37320 (Δ[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGGCTTGCCCCTTTCA, downstream forward: _UP4_TAACACTGGGGCATTCACAA
BKK37320 (Δ[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGGCTTGCCCCTTTCA, downstream forward: _UP4_TAACACTGGGGCATTCACAA
References
Reviews
Original Publications
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Time of last update: 2024-12-20 21:16:02
Author of last update: Melvin.boenninger