corA
168
general stress protein, similar to magnesium transporter
locus
BSU_24740
Molecular weight
37.55 kDa
pI
9.54
function
unknown
product
unknown
essential
no
synonyms
corA, yqhC, yqxL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0598 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,560,489 → 2,561,442
The protein
Catalyzed reaction/ biological activity
there is no indication for an implication of [protein|F0CACEFB53F4BC38DF77A38C4D78BA3DBE96E21A|corA] in Mg2 uptake (based on mutant phenotypes, failure to complement mutants defective in Mg2 uptake) [Pubmed|24415722]
Protein family
CorA metal ion transporter (MIT) (TC 1.A.35) family (together with [protein|D281B88EC444F8175AB50FB2CD24B51F4E2C96F8|yfjQ]) (according to UniProt)
Structure
[PDB|5JTG] (from Themotoga maritima, C-terminal domain, aa 122-297, 28% identity)
[AF|P40948]
[wiki|Localization]
inner spore membrane [Pubmed|26731423]
Expression and Regulation
Operons
genes
[gene|F0CACEFB53F4BC38DF77A38C4D78BA3DBE96E21A|corA]
description
[Pubmed|2507524]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
MGNA-C473 (yqxL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2471 NBRP B. subtilis, Japan]
BKE24740 (Δ[gene|F0CACEFB53F4BC38DF77A38C4D78BA3DBE96E21A|corA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCAAGCTCCTCCAAAC, downstream forward: _UP4_TAGGATGTTTCATATTTTGT
BKK24740 (Δ[gene|F0CACEFB53F4BC38DF77A38C4D78BA3DBE96E21A|corA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCAAGCTCCTCCAAAC, downstream forward: _UP4_TAGGATGTTTCATATTTTGT
References
Reviews
Original Publications
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Time of last update: 2024-12-18 18:51:07
Author of last update: Jstuelk