gerAA

gerAA
168

nutrient receptor, germination response to alanine, triggers premature germination in response to morphological defects during sporulation

Locus
BSU_33050
Molecular weight
53.62 kDa
Isoelectric point
8.8
Protein length
482 aaSequenceBlast
Gene length
1449 bpSequenceBlast
Function
germination response to alanine
Product
part of the nutrient-gated GerAA-GerAB-GerAC ion channel
Essential
no
Synonyms
gerAA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5901 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,390,782 → 3,392,230
Phenotypes of a mutant
suppresses the defects of spoVV mutant spores PubMed
The protein
Catalyzed reaction/ biological activity
the GerAA-GerAB-GerAC ion channel releases ions from the spore core in response to alanine to trigger Germination PubMed
transducer the nutrient signal sensed by GerAB
triggers premature germination in response to morphological defects during sporulation PubMed
Protein family
GerABKA family (according to UniProt)
Domains
contains multiple membrane-spanning domains PubMed
Structure
6O59 (PDB) (from B. megaterium, corresponds to aa 4 ... 256, 34% identity) PubMed
P07868 (AlphaFold)
Paralogous protein(s)
YndD, GerBA, YfkQ, GerKA
Localization
outer surface of the inner spore membrane PubMed
Additional information
1,100 molecules are present per spore PubMed
Expression and Regulation
Operons
Genes
gerAA-gerAB-gerAC
Description
PubMed
Regulation
expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: repression, PubMed, in spoVT regulon
Sigma factors
SigG: sigma factor, PubMed, in sigG regulon
SigF: sigma factor, PubMed, in sigF regulon
Additional information
1,100 molecules are present per spore PubMed
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gerAA→gerAC

2025-04-07 00:35:30

ghost

127

0b30e2b65ff83889103eaceb2726933679280f16

FB9C2DA86BEDDEDF47C18987147D4007D840E75A

Biological materials
Mutant
BKE33050 (ΔgerAA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATGAGGTCACCTCTTATC,  downstream forward: _UP4_AAACCAAAAGAGGTGAATAA
BKK33050 (ΔgerAA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATGAGGTCACCTCTTATC,  downstream forward: _UP4_AAACCAAAAGAGGTGAATAA
References
Reviews
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Original Publications
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EEDE6A22E91992ABCA677CAB7917B7168C5CB868

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Time of last update: 2025-04-11 11:17:09

Author of last update: Jstuelk