bmrA

bmrA
168

multidrug [wiki|ABC transporter] ([metabolite|ATP]-binding protein)

locus
BSU_34820
Molecular weight
64.34 kDa
pI
6.47
Protein length
589 aaSequenceBlast
Gene length
1770 bpSequenceBlast
function
multiple antibiotic resistance
product
multidrug [wiki|ABC transporter] ([metabolite|ATP]-binding protein)
essential
no
synonyms
bmrA, yvcC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1132 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,577,745 → 3,579,514
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
has both a membrane-spanning and an [metabolite|ATP]-binding domain [Pubmed|10092453]
[wiki|ABC transmembrane type-1 domain] (aa 29-309) (according to UniProt)
[wiki|ABC transporter domain] (aa 341-576) (according to UniProt)
Structure
[PDB|6R72] [pubmed|35080979]
[AF|O06967]
Paralogous protein(s)
[protein|70D7098BEBD5E53B4B9B8C3394FAAF972C65EE22|yknU], [protein|E85814EDF232D21A42380D559EAD2CDFB41F19DB|yfiC], [protein|D5A3C316BD4567A0155F70330E32ACDE18F063FE|ywjA], [protein|C6B0ACB9D9703DD8141FD7D9D62DB22FB48F458B|yknV], [protein|0EB4D3E1B9AF39ECCBD79EB559FAE5BB0EE4C156|ygaD], [protein|288CA73D93B1E5106E1C6CE5E7E2E8BE2A6BD3F3|yfiB], [protein|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]
[wiki|Localization]
membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]-[gene|EFF0635A4BBB62558A04BA49195D76234776F943|yvcD]
description
[pubmed|22383849]
regulation
constitutively expressed [Pubmed|21077936]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21077936], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
half-life of the mRNA: 1.5 min [PubMed|21077936]
Open in new tab

[gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]->[gene|EFF0635A4BBB62558A04BA49195D76234776F943|yvcD]

2024-12-21 12:17:59

Bzhu

100

cbb28df201cbb41f921589502974e179e1c5f328

D27A0048010333EF6A841E0CD3BADFB4A82AC446

Biological materials
Mutant
MGNA-B645 (yvcC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1644 NBRP B. subtilis, Japan]
BKE34820 (Δ[gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34820 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATATTTTCCTCCTGTTT,  downstream forward: _UP4_TAAATTTTGGTCGAATCAGC
BKK34820 (Δ[gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34820 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATATTTTCCTCCTGTTT,  downstream forward: _UP4_TAAATTTTGGTCGAATCAGC
References
Reviews
33450852
Original Publications
16107340,15182191,15766260,16405427,12968023,10092453,18215075,12225846,20544182,11827477,21077936,21336797,21483854,27570617,28755379,29662596,23716676,24630999,31044174,31924974,33198135,33212311,34948362,34988902,35080979,38072053,39397791

ED1F82463BAA28B67184BFAB5CB23CF26A62999D

Page visits: 4670

Time of last update: 2024-12-20 18:27:22

Author of last update: Jstuelk