rpsO
168
ribosomal protein uS15
locus
BSU_16680
Molecular weight
10.00 kDa
pI
10
function
translation
product
ribosomal protein S15 (uS15)
essential
yes
synonyms
rpsO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0184 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,738,941 → 1,739,210
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]
The protein
Protein family
universal [wiki|ribosomal protein] uS15 family (single member, according to UniProt)
Structure
[PDB|1A32] (''Geobacillus stearothermophilus'')
[PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
[AF|P21473]
Additional information
this ribosomal protein is lacking in some organisms with very small genomes [pubmed|33753464]
Expression and Regulation
Operons
genes
[gene|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO]
description
[Pubmed|19633085]
regulation
translational repression of ''rpsO'' expression upon binding of excess [protein|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO] to a [wiki|RNA switch] in the untranslated region of the ''rpsO'' mRNA [Pubmed|23611891,16005889]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
additional information
the mRNA is processed, this is initiated by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] and cleavage products are subsequently subject to exonucleolytic degradation by RNases [protein|3EB289D0F58A58C693AB588798EE66A731341999|J1] and [protein|B73CE26E7AEFACFA82C67F3E7DBBB3F766F739CA|J2] and by [protein|64C6D783FF3F41C81B216F798A1DC8071345B1ED|PNPase] [PubMed|20418391]
the [wiki|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
genes
[gene|85E732993186528CF58FECFFE89C8F39D278F28D|ribC]-[gene|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO]
description
[Pubmed|22383849]
additional information
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
References
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Time of last update: 2025-01-28 15:55:44
Author of last update: Jstuelk