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MntR and
manganese!
btr
168
transcriptional activator ([wiki|AraC family]), (AraC family DNA-binding domain fused to [protein|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-like substrate-binding domain), regulation of the [gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-[gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]-[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]-[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA] operon
Molecular weight
60.59 kDa
function
regulation of iron acquisition
product
transcription activator ([wiki|AraC family])
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
183,414 → 185,003
The protein
Catalyzed reaction/ biological activity
binding of a direct repeat in the [gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA] promoter region and transcription activation of the [gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-[gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]-[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]-[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA] operon in the presence of bacillibactin or enterobactin [Pubmed|17725565,22210890]
Protein family
[wiki|Domains]
[wiki|Fe/B12 periplasmic-binding domain] (aa 268-528) (according to UniProt)
[wiki|Cofactors]
enterobactin, bacillibactin (co-activators) [Pubmed|17725565]
Structure
Effectors of protein activity
enterobactin, bacillibactin (co-activators) [Pubmed|17725565]
Expression and Regulation
Operons
genes
[gene|EB28A65CECE994DF2DF486DEACF40F2533703DB0|btr]
description
[Pubmed|12354229]
regulation
expressed under conditions of iron starvation ([protein|search|Fur]) [Pubmed|12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
[gene|EB28A65CECE994DF2DF486DEACF40F2533703DB0|btr]
2024-10-09 11:16:36
ghost
61
9430f6b2596e4102cac0bd3b6434172ab65dac98
8E607D8530622210BCE389315103A110307A88DD
Biological materials
Mutant
MGNA-B949 (ybbB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1948 NBRP B. subtilis, Japan]
BKE01640 (Δ[gene|EB28A65CECE994DF2DF486DEACF40F2533703DB0|btr]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE01640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGAGTAGACCACCTTTTC, downstream forward: _UP4_TGATAAATCAGGAATTTGTC
BKK01640 (Δ[gene|EB28A65CECE994DF2DF486DEACF40F2533703DB0|btr]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK01640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGAGTAGACCACCTTTTC, downstream forward: _UP4_TGATAAATCAGGAATTTGTC
References
12884008,17725565,22210890,12354229,23199363,23504016
