dxs
168
1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis
locus
BSU_24270
Molecular weight
69.38 kDa
pI
6
function
biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis
product
1-deoxyxylulose-5-phosphate synthase
essential
yes
ec
2.2.1.7
synonyms
dxs, yqiE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1154 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,523,713 → 2,525,614
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
D-glyceraldehyde 3-phosphate + H+ + pyruvate --> 1-deoxy-D-xylulose 5-phosphate + CO2 (according to UniProt)
Protein family
transketolase family (with [protein|000E237B00539E6850B6A50EE01BA02844B6ACBC|tkt], according to UniProt)
[wiki|Cofactors]
TPP [pubmed|35988322]
Structure
[PDB|2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]
[AF|P54523]
Expression and Regulation
Operons
genes
[gene|EA9FCF84AE4FA80993566B62A9200D4B32AF5670|dxs]-[gene|923C4177500E9678A0B4855F8F481D4A36ECD863|tlyA]-[gene|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC]-[gene|5680A06A74D3EC6310EF8677795511C75DB3059E|recN]
description
[pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]
References
Reviews
Original Publications
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Time of last update: 2024-12-22 00:27:30
Author of last update: Jstuelk