resE
168
two-component sensor kinase, regulation of aerobic and anaerobic respiration
locus
BSU_23110
Molecular weight
66.60 kDa
pI
5.34
function
regulation of aerobic and anaerobic respiration
product
two-component sensor kinase
essential
no
synonyms
resE, ypxE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5002 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,415,415 → 2,417,184
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
two transmembrane segments
[wiki|HAMP domain] (aa 194-246) (according to UniProt)
[wiki|PAS domain] (aa 253-320) (according to UniProt)
[wiki|Histidine kinase domain] (aa 371-589) (according to UniProt)
Structure
[PDB|4ZR7] (N-terminal domain)
[AF|P35164]
Modification
autophosphorylation on a His residue
Paralogous protein(s)
[protein|C81F68521F17861D50926D7D8757DC1D2340BC0D|phoR], [protein|E88978809272FAC2520DB4ABCA0554F8028F3451|walK]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]-[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|22383849]
genes
[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [PubMed|8631715,11222591], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9988472], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|16825793], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8631715], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
Biological materials
Mutant
BKE23110 (Δ[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23110 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCTACTACGCTTTTCCAAA, downstream forward: _UP4_TAAAATCGAGTCTGAATTTG
BKK23110 (Δ[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23110 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCTACTACGCTTTTCCAAA, downstream forward: _UP4_TAAAATCGAGTCTGAATTTG
References
Reviews
Original Publications
Page visits: 11690
Time of last update: 2024-12-19 19:52:34
Author of last update: Melvin.boenninger