comGB
168
polytopic membrane protein, DNA transport machinery
locus
BSU_24720
Molecular weight
36.90 kDa
pI
8.65
function
genetic competence, DNA uptake
product
DNA transport machinery
essential
no
synonyms
comGB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1459 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,557,983 → 2,558,954
The protein
Protein family
GSP F family (single member, according to UniProt)
Structure
[AF|P25954]
[wiki|Localization]
cell membrane, polar localization [Pubmed|15083159,21278288]
Expression and Regulation
Operons
genes
[gene|41DFEF8A6BC7E34A6681C26D92F2B08DC120A957|comGA]-[gene|EA1C841FC77A1994A85E2E0C0A554482C3EC9323|comGB]-[gene|19D76B80386F825109C5FB4A34881D5D20F366DB|comGC]-[gene|D323AEF5AFB4FD2A074ABAB76A39BE26A4C6436F|comGD]-[gene|FF4DB7FDCEB440064E11E65CB0DBFB93FC785CF0|comGE]-[gene|DD266DC0D78B5C5E82EED7CC7F55D0CF8FB4BF7A|comGF]-[gene|89442BFDFBFF264D0C7F12DEA6F8130C55D1F3F8|comGG]-[gene|8F3751A3D0910C9BED7FBCE90AFF7FDACFDCBC0B|spoIIIL]
description
[Pubmed|26735940,2507524]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|26735940]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|8196543], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2507524], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|26735940], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
additional information
the ''[wiki|comGA]-[wiki|comGB]-[wiki|comGC]-[wiki|comGD]-[wiki|comGE]-[wiki|comGF]-[wiki|comGG]-[protein|search|spoIIIL]'' operon requires [wiki|NusA] for expression [http://www.nature.com/articles/nmicrobiol20157 Reference]
Biological materials
Mutant
BKE24720 (Δ[gene|EA1C841FC77A1994A85E2E0C0A554482C3EC9323|comGB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCACCGAGCCTCTTTA, downstream forward: _UP4_AATCAAATGTGAAAGGAAGA
BKK24720 (Δ[gene|EA1C841FC77A1994A85E2E0C0A554482C3EC9323|comGB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCACCGAGCCTCTTTA, downstream forward: _UP4_AATCAAATGTGAAAGGAAGA
BP914 (Δ([gene|41DFEF8A6BC7E34A6681C26D92F2B08DC120A957|comGA]-[gene|EA1C841FC77A1994A85E2E0C0A554482C3EC9323|comGB]-[gene|19D76B80386F825109C5FB4A34881D5D20F366DB|comGC]-[gene|D323AEF5AFB4FD2A074ABAB76A39BE26A4C6436F|comGD]-[gene|FF4DB7FDCEB440064E11E65CB0DBFB93FC785CF0|comGE]-[gene|DD266DC0D78B5C5E82EED7CC7F55D0CF8FB4BF7A|comGF]-[gene|89442BFDFBFF264D0C7F12DEA6F8130C55D1F3F8|comGG])::phleo), available in [wiki|Fabian Commichau]'s lab
References
Reviews
Original Publications
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Time of last update: 2024-10-04 10:20:41
Author of last update: Jstuelk