mrpA
168
Na+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis
locus
BSU_31600
Molecular weight
86.23 kDa
pI
9.52
function
sodium export
product
Na+/H+ antiporter subunit
essential
yes
synonyms
mrpA, yufT, shaA, ntrA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2111 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,246,679 → 3,249,003
Phenotypes of a mutant
essential [Pubmed|12682299]
a ''[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]'' mutant is viable at pH7.4 and sodium concentrations below 80 mM [Pubmed|24139955]
the ''[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]'' mutant accumulates internal sodium [Pubmed|24139955]
The protein
Catalyzed reaction/ biological activity
Na transporter subunit of the Na /H antiporter [Pubmed|21236240]
Protein family
CPA3 antiporters (TC 2.A.63) subunit A family (single member, according to UniProt)
Structure
[PDB|4HE8] (from ''Thermus thermophilus'', 36% identity in a 57% fragment) [Pubmed|23417064]
[AF|Q9K2S2]
[wiki|Localization]
inner spore membrane [Pubmed|26731423]
Expression and Regulation
Operons
genes
[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]-[gene|AAB15E7E3E3701AA3159370B85C151994244BA5B|mrpB]-[gene|D921139B18A665E9BB177C973FCF050A4BFFF97F|mrpC]-[gene|051D9BCC0CB05E39ED5825BB9BA77B8228EA055D|mrpD]-[gene|BF233467FAF95EEEE12A0D36C543DB357D8879EA|mrpE]-[gene|5CA2EA2D60FE4696903C16698C8329A20CBEBF72|mrpF]-[gene|B28796716C7E6C924F55176453DDBF9ADD0EF755|mrpG]
description
[Pubmed|9274030,10198001]
Biological materials
Mutant
MGNA-B557 (yufT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1556 NBRP B. subtilis, Japan]
References
Reviews
Original Publications
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Time of last update: 2024-12-28 03:45:36
Author of last update: Jstuelk