sufC

sufC
168

[wiki|ABC transporter] (ATP-binding protein), synthesis of Fe-S clusters

locus
BSU_32710
Molecular weight
28.88 kDa
pI
4.62
Protein length
Gene length
function
synthesis of Fe-S clusters
product
[wiki|ABC transporter] (ATP-binding protein)
essential
yes
synonyms
sufC, yurY

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0396 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,359,995 3,360,780
Phenotypes of a mutant
essential [Pubmed|12682299]
the mutant is viable and Fe-S clusters are dispensable if [protein|search|IspG ]and [protein|search|IspH ]from the MEP pathway for isoprenoid biosynthesis are bypassed by a heterologous mevalonate pathway which allows B. subtilis to synthesize isopentenyl diphosphate and diphosphomevalonate [pubmed|29292548]
The protein
Catalyzed reaction/ biological activity
synthesis of Fe-S-clusters (the [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]-[protein|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD] complex) [pubmed|29292548]
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 6-248) (according to UniProt)
Structure
[PDB|5AWF] (from ''E. coli'', the [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]-[protein|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD] complex, 51% identity) [Pubmed|26472926]
[AF|P80866]
Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[gene|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD]-[gene|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]-[gene|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]-[gene|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|E966F3808222820C0644DC98F95765B89E6A2551|sufC]→[gene|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]

2024-10-11 05:53:19

Bzhu

114

63d79455b7d41fde1312877ed8143d20d826635d

39B630142CB404BA5FE5465E795D5B1BB8CA4EF6

Biological materials
Mutant
MGNA-B587 (yurY::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1586 NBRP B. subtilis, Japan]
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([wiki|BACTH]), available in [wiki|Jrg Stlke]'s lab
References
Reviews
34781750,38838856
Original Publications
10092453,20097860,16493705,22383849,15378759,26472926,27179343,29292548,36815589

E966F3808222820C0644DC98F95765B89E6A2551

Page visits: 4444

Time of last update: 2024-10-14 16:10:10

Author of last update: Jstuelk