atpH
168
ATP synthase, part of the F1 complex (subunit delta)
locus
BSU_36840
Molecular weight
19.84 kDa
pI
9.57
function
ATP synthesis
product
ATP synthase (subunit delta)
essential
no
synonyms
atpH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0712 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,785,403 → 3,785,948
The protein
Catalyzed reaction/ biological activity
ATP synthesis [http://www.youtube.com/watch?v=uOoHKCMAUMc see a video]
Protein family
ATPase delta chain family (single member, according to UniProt)
Structure
[PDB|5T4O] (ATPase from E. coli, 25% identity) [pubmed|28001127]
[AF|P37811]
Modification
phosphorylated on Arg-159 [Pubmed|22517742]
Effectors of protein activity
ATPase activity is inhibited upon binding of Mg-ADP to [protein|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD] [pubmed|30580998]
[wiki|Localization]
membrane (Heterogeneous) [Pubmed|16479537]
peripheral via the F0 complex
http://subtiwiki.uni-goettingen.de/v3/gene/view/E956A30D97B2941108880F3AD48620C4DB6E0EBD
Expression and Regulation
Operons
genes
[gene|8027AD5C3A92FB9B70E42C119FDEC697A64618C4|atpI]-[gene|CC1894D90AC17487A286B2909964916825055F93|atpB]-[gene|6CF7F6303425D8A51E1E01BF18823139E4259A8F|atpE]-[gene|87311FEA265AD3F5526C78D631E7E51BBF01F0D6|atpF]-[gene|E956A30D97B2941108880F3AD48620C4DB6E0EBD|atpH]-[gene|E3FADE979CE6AB6315F67812608FCE00CF4E2453|atpA]-[gene|492EEC8068043DA770F5DC1D54799C4366AE9A01|atpG]-[gene|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD]-[gene|A9DA64F8C7A60E8E2B1EDC99BEA1BD7DD0135AA6|atpC]
description
[Pubmed|9353933]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
the mRNA is processed between [gene|8027AD5C3A92FB9B70E42C119FDEC697A64618C4|atpI] and [gene|CC1894D90AC17487A286B2909964916825055F93|atpB] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
Biological materials
Mutant
BKE36840 (Δ[gene|E956A30D97B2941108880F3AD48620C4DB6E0EBD|atpH]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCGTTTAGAGACAGCTGATC, downstream forward: _UP4_AATCGATAGAAGGGGTGAAA
BKK36840 (Δ[gene|E956A30D97B2941108880F3AD48620C4DB6E0EBD|atpH]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCGTTTAGAGACAGCTGATC, downstream forward: _UP4_AATCGATAGAAGGGGTGAAA
References
Reviews
Original Publications
Page visits: 3185
Time of last update: 2024-12-19 18:40:39
Author of last update: Jstuelk