fni

fni
168

isopentenyl diphosphate isomerase, last (8th) step in the MEP pathway of isoprenoid biosynthesis

locus
BSU_22870
Molecular weight
22.45 kDa
pI
6.1
Protein length
349 aaSequenceBlast
Gene length
1050 bpSequenceBlast
function
MEP pathway of isoprenoid biosynthesis
product
isopentenyl diphosphate isomerase
essential
no
ec
5.3.3.2
synonyms
fni, ypgA, idi
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1304 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,393,602 → 2,394,651
The protein
Catalyzed reaction/ biological activity
isopentenyl diphosphate --> dimethylallyl diphosphate (according to UniProt)
Protein family
IPP isomerase type 2 family (single member, according to UniProt)
Structure
[PDB|1P0N] (complex with FMN)
[PDB|1P0K]
[AF|P50740]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]-[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|rpsA]-[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]
description
[pubmed|22383849]
Open in new tab

[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]→[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]

2024-10-11 06:23:44

Jstuelk

110

b56967b84c1bb47ba8c616de4931b2c8bed64802

1B9CB16A7EDCD5BF30213E1E4311C8B2D2B02BB4

genes
[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|rpsA]-[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]
description
[pubmed|22383849]
Open in new tab

[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|rpsA]→[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]

2024-10-10 13:08:24

Jstuelk

103

59f3916fce3e48c8c6ff7f585f1bca41eb2e3c88

5FF221244B4F9D377716054C5E17F60067F95631

genes
[gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]-[gene|3459BA0CDAABC288ADF97B111F78C7EAC184840D|ypfB]-[gene|1ADB6E2C8DC82A242CFEFAD22443D14226F1BA60|cmk]-[gene|7C36409F155E4C91CEE902FE6937571BD0C50128|rpsA]-[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]
description
[pubmed|22383849]
Open in new tab

[gene|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI]→[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]

2024-10-11 02:22:04

Jstuelk

129

40589d593f2ed9acd667e06cee390577206bc679

B16C0E2FDCD0AB8461F12841F5F6E879CEC5BE2C

Biological materials
Mutant
MGNA-A420 (ypgA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/420 NBRP B. subtilis, Japan]
BKE22870 (Δ[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22870 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCTCGAGTCACGTTTATCA,  downstream forward: _UP4_TAAATGATAAAAGCCCAAAA
BKK22870 (Δ[gene|E91624382EC3DAABFB3123CDA818B4BEF745ACE6|fni]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22870 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCTCGAGTCACGTTTATCA,  downstream forward: _UP4_TAAATGATAAAAGCCCAAAA
References
12798687,17458547,14745175,23840410,35643569

E91624382EC3DAABFB3123CDA818B4BEF745ACE6

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Time of last update: 2024-10-13 04:44:23

Author of last update: Jstuelk