licA
168
lichenan-specific permease of the [wiki|phosphotransferase systems|phosphotransferase system], EIIA of the [category|SW.1.2.2|PTS]
locus
BSU_38570
Molecular weight
12.04 kDa
pI
4.64
function
lichenan uptake and phosphorylation
product
lichenan-specific [category|SW.1.2.2|PTS], EIIA component
essential
no
synonyms
licA, celC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1447 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,959,841 → 3,960,173
The protein
Protein family
[category|SW.1.2.2|PTS] permease, lactose family [Pubmed|10627040]
[wiki|Domains]
[wiki|PTS EIIA domain] type-3 (aa 3-101) (according to UniProt)
Structure
[PDB|3K1S] (IIA(Cel) from ''B. anthracis'', 42% identity)
[AF|P46319]
Paralogous protein(s)
[protein|44014896157718D3A6190DFDBD663C5CB9DA63FC|gmuA]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|65FC7F4ED92F747DB7BC5672DCA2D2320A471134|licB]-[gene|83A7C160B0301A2B51B65478D99ACB753D67AF74|licC]-[gene|E8B6C8E722BEE866878CDD816B7828C132F94FCD|licA]-[gene|84D8AA0AFBF46273F6B4198B49440D55470FEC0F|licH]
description
[Pubmed|8990303]
regulation
carbon catabolite repression ([protein|search|CcpA]) [Pubmed|8990303]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|8990303], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E087ABA705CE94E2CAD44A0F2FB265B0F7B04399|licR]: activation, [Pubmed|8990303], in [regulon|protein:E087ABA705CE94E2CAD44A0F2FB265B0F7B04399|licR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8990303], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE38570 (Δ[gene|E8B6C8E722BEE866878CDD816B7828C132F94FCD|licA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTCACGCGATTCACTTCCT, downstream forward: _UP4_ACCGAGCAAAGGGGAGCAAG
BKK38570 (Δ[gene|E8B6C8E722BEE866878CDD816B7828C132F94FCD|licA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTCACGCGATTCACTTCCT, downstream forward: _UP4_ACCGAGCAAAGGGGAGCAAG
References
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Time of last update: 2024-10-10 17:24:47
Author of last update: Melvin.boenninger