serC
168
3-phosphoserine aminotransferase
locus
BSU_10020
Molecular weight
39.98 kDa
pI
5.52
function
biosynthesis of serine
product
3-phosphoserine aminotransferase
essential
no
ec
2.6.1.52
synonyms
serC, yhaF, glyB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1932 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,075,289 1,076,368
The protein
Catalyzed reaction/ biological activity
2-oxoglutarate + O-phospho-L-serine --> 3-phosphooxypyruvate + L-glutamate (according to UniProt)
2-oxoglutarate + 4-(phosphooxy)-L-threonine --> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate (according to UniProt)
Protein family
[wiki|Class-V pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP
Structure
[PDB|1W23] (from ''Bacillus alcalophilus'', 59% identity) [Pubmed|15608117]
[AF|P80862]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|E7ED2FB756B47A0F2C73E42E4168D16F20BD7B1B|serC]-[gene|97573C2D4FD8BE6B4C749C0644D053C9A0CBFFF3|trpP]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-A685 (serC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/685 NBRP B. subtilis, Japan]
1A621 ( ''serC''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A621&Search=1A621 BGSC]
BKE10020 ([gene|E7ED2FB756B47A0F2C73E42E4168D16F20BD7B1B|serC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATGATCTCTCCCTGTT, downstream forward: _UP4_TAAAAAGTCTGGCTATGCAA
BKK10020 ([gene|E7ED2FB756B47A0F2C73E42E4168D16F20BD7B1B|serC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATGATCTCTCCCTGTT, downstream forward: _UP4_TAAAAAGTCTGGCTATGCAA
BP1274 ([gene|E7ED2FB756B47A0F2C73E42E4168D16F20BD7B1B|serC]::ermC trp+) available in [wiki|Jörg Stülke]'s & [wiki|Fabian Commichau]'s lab
References
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Time of last update: 2024-12-22 00:58:11
Author of last update: Melvin.boenninger