fecF
168
iron/citrate ABC transporter ([metabolite|ATP]-binding protein)
locus
BSU_07490
Molecular weight
29.31 kDa
pI
6.07
function
iron uptake
product
iron/citrate ABC transporter ([metabolite|ATP]-binding protein)
essential
no
ec
3.6.3.-
synonyms
fecF, yfmF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1120 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
822,903 → 823,703
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 4-240) (according to UniProt)
Structure
[PDB|4G1U] (from ''Yersinia pestis'', the [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[protein|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF] complex, 32% identity) [Pubmed|23142986]
[AF|O34510]
Paralogous protein(s)
[protein|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC], [protein|473628F86C18FE9957841F3C8B45242C90CB341D|fpbP], [protein|5C52DB31F378E49AABE5D937DD901A68F3810477|yusV]
[wiki|Localization]
associated to the membrane (via [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]) [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]-[gene|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[gene|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[gene|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]
description
[Pubmed|16672620]
regulation
immediately induced upon iron starvation (first wave to allow iron uptake) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,16672620,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [Pubmed|16672620,12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
MGNA-C244 (yfmF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2242 NBRP B. subtilis, Japan]
BKE07490 (Δ[gene|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAGTTTTCCCATGGTATCCT, downstream forward: _UP4_TGAAAAGGAGAGGAATTCCC
BKK07490 (Δ[gene|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAGTTTTCCCATGGTATCCT, downstream forward: _UP4_TGAAAAGGAGAGGAATTCCC
References
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Time of last update: 2024-12-21 11:46:10
Author of last update: Jstuelk