tagF
168
CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase
locus
BSU_35720
Molecular weight
87.87 kDa
pI
9.4
function
biosynthesis of teichoic acid
product
CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase
essential
yes
ec
2.7.8.12
synonyms
tagF, rodC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1887 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,676,159 → 3,678,399
Phenotypes of a mutant
essential [Pubmed|12682299]
knockdown of expression results in loss of [category|SW.5.2.1|ICEBs1] conjugation (both in donor and recipient cells) [pubmed|35490406]
The protein
Catalyzed reaction/ biological activity
4-O-[(2R)-glycerylphospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol --> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H+ (according to UniProt)
Protein family
CDP-glycerol glycerophosphotransferase family (with [protein|911A4D957A6C0DFC636A152395119DBFC777DDA2|tagB], according to UniProt)
Structure
[PDB|3L7I] (C-terminal domain of the Staphylococcus epidermidis protein, 48% identity) [pubmed|20400947]
[AF|P13485]
[wiki|Localization]
membrane associated [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD]-[gene|88028A5F3520CB6DAB014412974EB59CC5D226DD|tagE]-[gene|E730E41546298960A4B907FCB7F36C495AA9602B|tagF]-[gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]
description
[Pubmed|22383849]
regulation
repressed by phosphate ([protein|search|PhoP]) [Pubmed|9457886]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: repression, [Pubmed|9457886], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: activation, [Pubmed|12950927], in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7581998], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
Reviews
Original Publications
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Time of last update: 2024-10-08 19:20:42
Author of last update: Jstuelk