fhuC
168
hydroxamate siderophore [wiki|ABC transporter ]([metabolite|ATP]-binding protein) (ferrichrome und ferrioxamine)
locus
BSU_33290
Molecular weight
29.80 kDa
pI
6.5
function
siderophore uptake
product
hydroxamate siderophore [wiki|ABC transporter ]([metabolite|ATP]-binding protein) (ferrichrome und ferrioxamine)
essential
no
ec
3.6.3.34
synonyms
fhuC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1120 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,415,387 → 3,416,196
The protein
Catalyzed reaction/ biological activity
ATP + H2O + Fe3+-hydroxamate complex-[hydroxamate-binding protein](Side 1) --> ADP + phosphate + Fe3+-hydroxamate complex(Side 2) + [hydroxamate-binding protein] (according to UniProt)
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 4-240) (according to UniProt)
Structure
[PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuD shares 34% identity, 55% similarity with FhuC, [Pubmed|25402482]
[AF|P49938]
Paralogous protein(s)
[protein|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF], [protein|5C52DB31F378E49AABE5D937DD901A68F3810477|yusV], [protein|473628F86C18FE9957841F3C8B45242C90CB341D|fpbP]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]-[gene|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG]-[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]
description
[pubmed|22383849]
regulation
induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [pubmed|29133393,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
BKE33290 (Δ[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAA
BKK33290 (Δ[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAA
References
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Time of last update: 2024-12-30 13:45:59
Author of last update: Jstuelk