cydB
168
cytochrome bd ubiquinol oxidase (subunit II), high affinity terminal oxidase
locus
BSU_38750
Molecular weight
37.70 kDa
pI
9.48
function
respiration
product
cytochrome bd ubiquinol oxidase (subunit II), high affinity terminal oxidase
essential
no
synonyms
cydB, yxkL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1294 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,976,791 → 3,977,807
The protein
Catalyzed reaction/ biological activity
2 ubiquinol + n H+ + O2 --> 2 ubiquinone + n H+ + 2 H2O (according to UniProt)
Protein family
cytochrome ubiquinol oxidase subunit 2 family (with [protein|813E4BBEC8701114503ACD66DD6FE5A06B6B5E5F|ythB], according to UniProt)
[wiki|Cofactors]
heme b, heme d (according to UniProt)
Structure
[AF|P94365]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]-[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]-[gene|A65576E0261F1950A0DAD72B2432D97AB3EB2AA5|cydC]-[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
description
[Pubmed|16207915]
regulation
expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|17322317]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]: repression, [Pubmed|15231791], in [regulon|protein:B5EF521437323EF43F08E5EFDB5C798616CA499A|rex regulon]
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|17322317], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [PubMed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
Biological materials
Mutant
MGNA-B746 (cydB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1745 NBRP B. subtilis, Japan]
BKE38750 (Δ[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38750 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCATGAAGAGATGCCATG, downstream forward: _UP4_CATAAGGAGCCTATGACTTA
BKK38750 (Δ[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38750 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCATGAAGAGATGCCATG, downstream forward: _UP4_CATAAGGAGCCTATGACTTA
References
Reviews
Original Publications
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Time of last update: 2024-12-21 11:33:22
Author of last update: Jstuelk