yisP
168
farnesyl diphosphate phosphatase, production of farnesol
locus
BSU_10810
Molecular weight
31.35 kDa
pI
7.26
function
control of [protein|A656321846B2E0D1F39B528E2D8B8E620CCD1148|kinC] activity
product
farnesyl diphosphate phosphatase
essential
no
synonyms
yisP, yucD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1562 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,159,922 → 1,160,746
Phenotypes of a mutant
complete loss of pellicle-forming ability [Pubmed|20713508]
reduced [wiki|protein secretion] [Pubmed|23651456]
The protein
Catalyzed reaction/ biological activity
farnesyl diphosphate -→ farnesol [Pubmed|25308276]
Protein family
phytoene/squalene synthase family (single member, according to UniProt)
[wiki|Cofactors]
NADH [Pubmed|20713508]
Structure
[PDB|3WE9] [Pubmed|25308276]
[AF|O06728]
Expression and Regulation
Operons
genes
[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]
description
[pubmed|22383849]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|26577401], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
MGNA-B190 (yisP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1189 NBRP B. subtilis, Japan]
BKE10810 (Δ[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGCTTCTTCAAGTCTAG, downstream forward: _UP4_TAAAAAACACCCGGCCTTGA
BKK10810 (Δ[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGCTTCTTCAAGTCTAG, downstream forward: _UP4_TAAAAAACACCCGGCCTTGA
References
Reviews
Original Publications
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Time of last update: 2024-12-21 23:13:22
Author of last update: Jstuelk