hemH
168
coproporphyrin ferrochelatase
locus
BSU_10130
Molecular weight
35.19 kDa
pI
4.62
function
biosynthesis of heme
product
coproporphyrin ferrochelatase
essential
no
ec
4.99.1.1
synonyms
hemH, hemF, cpfC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0276 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,087,250 → 1,088,182
The protein
Catalyzed reaction/ biological activity
coproporphyrin --> coproheme [pubmed|25646457]
2 H+ + heme b --> Fe2+ + protoporphyrin IX (according to UniProt)
Protein family
ferrochelatase family (with [protein|8BAB9B12D9D58A45446DC6CB7F48869089800FD3|ylnF], according to UniProt)
Structure
[PDB|2HK6] (complex with iron) [pubmed|17198378]
[PDB|1AK1] [pubmed|9384565]
[AF|P32396]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]-[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]-[gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]
description
[Pubmed|1459957]
Biological materials
Mutant
BKE10130 (Δ[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
BKK10130 (Δ[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
References
Reviews
Original Publications
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Time of last update: 2025-04-09 21:01:59
Author of last update: Jstuelk