menD
168
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase
locus
BSU_30820
Molecular weight
63.92 kDa
pI
5.66
function
biosynthesis of menaquinone
product
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase
essential
yes
ec
2.2.1.9
synonyms
menD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1165 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,150,563 → 3,152,305
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
2-oxoglutarate + H+ + isochorismate --> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 (according to UniProt)
Protein family
[wiki|TPP enzyme family] (according to UniProt)
[wiki|Cofactors]
thiamine pyrophosphate, divalent metal ion such as Mn(2+)) [Pubmed|20600129]
Structure
[PDB|2X7J] [Pubmed|20600129]
[AF|P23970]
Expression and Regulation
Operons
genes
[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163,8550504]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
References
Reviews
Original Publications
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Time of last update: 2024-12-19 14:01:04
Author of last update: Jstuelk