epeP
168
membrane protease, processing of modified [protein|D66B9BFF79ADD8B0F9BFA3892FCF4597264CE9EE|epeX]
locus
BSU_40160
Molecular weight
29.72 kDa
pI
9.64
function
control of [protein|49E70A20CC05DBE485953C0AE34E634EFB33C3B2|liaR]-[protein|9A1871BD853254EEA8B4E78CA187F9315CBDF43D|liaS] activity
product
membrane protease
essential
no
synonyms
yydH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
4,125,742 → 4,126,500
The protein
Catalyzed reaction/ biological activity
processing of modified [protein|D66B9BFF79ADD8B0F9BFA3892FCF4597264CE9EE|epeX], results in mature peptide (residues 33-49) [pubmed|28644475]
Protein family
[wiki|peptidase M50B family] (according to UniProt)
Structure
[PDB|3B4R] (aa 92 ... 224, zinc metalloprotease from Methanocaldococcus jannaschii, 24% identity) [pubmed|18063795]
[AF|Q45594]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|D66B9BFF79ADD8B0F9BFA3892FCF4597264CE9EE|epeX]-[gene|25FC87037222084ABE318813959101016FEB49DF|epeE]-[gene|E280A5994F4D9D93DA4B698E79C86360DBEE5396|epeP]-[gene|1BF1A48CF645249CA9ECBB19C04B059B11D821EF|epeA]-[gene|A4213DE6C9BE29405B0A4C0A969A78EA4C5EB71F|epeB]
description
[Pubmed|17921301]
regulation
repressed during logarithmic growth ([protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]) [Pubmed|17921301]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|34120110,17921301], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
[protein|1508770D5BCA5739D13E3ABD11CC5C103C07FF25|rok]: repression, [Pubmed|15743949], in [regulon|protein:1508770D5BCA5739D13E3ABD11CC5C103C07FF25|rok regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17921301], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B809 (yydH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1808 NBRP B. subtilis, Japan]
BKE40160 (Δ[gene|E280A5994F4D9D93DA4B698E79C86360DBEE5396|epeP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40160 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTCATACTTTAAAATTTTC, downstream forward: _UP4_TAGAGTAAAAGATCTCCAAA
BKK40160 (Δ[gene|E280A5994F4D9D93DA4B698E79C86360DBEE5396|epeP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40160 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTCATACTTTAAAATTTTC, downstream forward: _UP4_TAGAGTAAAAGATCTCCAAA
References
Reviews
Original Publications
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Time of last update: 2024-12-20 21:54:38
Author of last update: Jstuelk