infC
168
translation initiation factor IF-3, prevents premature docking of 50S ribosomal subunits
locus
BSU_28870
Molecular weight
19.59 kDa
pI
10.34
function
translation
product
initiation factor IF-3
essential
yes
synonyms
infC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0290 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,952,828 → 2,953,349
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
prevents premature docking of 50S ribosomal subunits [pubmed|15755955,26259514]
Protein family
IF-3 family (single member, according to UniProt)
Structure
[PDB|1TIF] (N-terminal domain, Geobacillus stearothermophilus), [PDB|1TIG] (C-terminal domain, Geobacillus stearothermophilus)
[AF|P55872]
Expression and Regulation
Operons
genes
[gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC]-[gene|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|rpmI]-[gene|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]-[gene|19349FDFE0F9A46FCCAA684B8139E592979DB317|ysdA]
description
[Pubmed|17289755]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]: termination, via binding to a [wiki|RNA switch] in the [gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC] leader region causes transcription termination, in [regulon|protein:803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT regulon]
additional information
autorepression of [gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC]-[gene|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|rpmI]-[gene|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]-[gene|19349FDFE0F9A46FCCAA684B8139E592979DB317|ysdA] expression upon binding of excess [protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT] to the untranslated region of the mRNA [Pubmed|29925569,17616982]
expression of [protein|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|IF3 ]is uncoupled from that of [protein|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|L35 ]and [protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|L20 ]by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y]-dependent mRNA processing [PubMed|21843271]
the [wiki|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
References
Reviews
Original Publications
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Time of last update: 2025-01-29 15:13:26
Author of last update: Jstuelk