pghC
168
phage-derived gamma polyglutamic acid hydrolase
locus
BSU_17270
Molecular weight
26.72 kDa
pI
8.3
function
polyglutamic acid degradation
product
phage-derived gamma polyglutamic acid hydrolase
essential
no
synonyms
pghC, ymaC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4195 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,863,448 → 1,864,155
The protein
Catalyzed reaction/ biological activity
hydrolysis of polyglutamic acid [Pubmed|26158264]
Protein family
[wiki|UPF0714 family] (according to UniProt)
[wiki|Domains]
DUF867 [http://pfam.xfam.org/family/PF05908 x], [[gamma-PGA hydrolase domain]] [Pubmed|26158264]
Structure
[PDB|3A9L] (from B. subtilis phage NIT1, 40% identity) [pubmed|22105902]
[AF|O31789]
Paralogous protein(s)
[protein|FD862CE6C4A37B17714F8F8687B3266D43EF5F63|pghL], [protein|8F9DCD77660706E4D25CD7875C014F6A2B5D8123|pghZ], [protein|BA7D1D112E934B68073DFC1F76248ED6157240E3|pghB]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|DF95DED9A6E2160C151D7664C951B198EEA225E8|pghC]-[gene|0785B4C70C3DD00EFB8BCDD91EF4F98EF4372186|ymaD]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE17270 (Δ[gene|DF95DED9A6E2160C151D7664C951B198EEA225E8|pghC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17270 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTAACTCCTTTCATA, downstream forward: _UP4_TAACAAGCAGATCAGAAGAC
BKK17270 (Δ[gene|DF95DED9A6E2160C151D7664C951B198EEA225E8|pghC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17270 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTAACTCCTTTCATA, downstream forward: _UP4_TAACAAGCAGATCAGAAGAC
References
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Time of last update: 2024-12-02 00:42:34
Author of last update: Melvin.boenninger