metS

metS
168

methionyl-tRNA synthetase

locus
BSU_00380
Molecular weight
76.01 kDa
pI
4.96
Protein length
Gene length
function
translation
product
methionyl-tRNA synthetase
essential
yes
ec
6.1.1.10
synonyms
metS, metG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0143 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
45,633 → 47,627
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-methionine + tRNAMet --> AMP + diphosphate + L-methionyl-tRNAMet (according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
[wiki|Domains]
[wiki|tRNA-binding domain] (aa 570-662) (accordinig to UniProt)
Structure
[PDB|1WE0] (from ''Thermus thermophilus hb8 mutant'', 40% identity, 57% similarity) [Pubmed|10673435]
[AF|P37465]
Modification
phosphorylated on Ser-652 [Pubmed|20509597]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|DCBDD135F295B04FE7C7EB92E94638701CB320DD|metS]-[gene|00798BB5A769C464CC5FDDF7D9E41D30B473B9A8|yabD]
description
[Pubmed|22383849] null
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of [gene|DCBDD135F295B04FE7C7EB92E94638701CB320DD|metS] [Pubmed|27120414]
Open in new tab

[gene|DCBDD135F295B04FE7C7EB92E94638701CB320DD|metS]→[gene|00798BB5A769C464CC5FDDF7D9E41D30B473B9A8|yabD]

2024-11-14 01:37:19

Jstuelk

57

8ca1bbc067765c91c7da7f4f4ed3d0aa9caba36e

4F14621DA97D6D58D4492DEB992381F4E9551CCD

genes
[gene|DCBDD135F295B04FE7C7EB92E94638701CB320DD|metS]
description
null
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of [gene|DCBDD135F295B04FE7C7EB92E94638701CB320DD|metS] [Pubmed|27120414]
Open in new tab

[gene|DCBDD135F295B04FE7C7EB92E94638701CB320DD|metS]

2024-11-14 01:10:43

Jstuelk

53

6ab79c761842accec71a7cc531e97d6cfd5e4e5c

DEDD9440958FF3B880F689E489D5FEB912287534

References
14651647,20509597,27120414,11732605

DCBDD135F295B04FE7C7EB92E94638701CB320DD

Page visits: 5206

Time of last update: 2024-12-03 22:28:13

Author of last update: Robert.warneke