wprA

wprA
168

secreted quality control protease

locus
BSU_10770
Molecular weight
96.29 kDa
pI
9.58
Protein length
Gene length
function
protein quality control
product
secreted quality control protease
essential
no
synonyms
wprA, yisM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1404 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,153,789 → 1,156,473
The protein
Catalyzed reaction/ biological activity
important for [protein|780FDF3DD260287428B397FFE7F44DDF1917381C|tatAY]-[protein|E60FC9C9B273DD6B07B7B95819525DE5F35113CE|tatCY]-dependent export of [protein|253A24EEA02C07E577A96FB64DF39F9A3D0C3A52|ykuE] and [protein|3985F88334D7B034A66473C5BB39188AB61A65F6|efeB] [Pubmed|23180473]
involved in degradation of [protein|6EE13E61A218A6D52BAC83A1145B0B96961CE289|prsA], [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|htrA], and [protein|796216BE9CD6DADFEADC29497253C81BF496A2ED|htrB] [Pubmed|24362423]
Protein family
[wiki|peptidase S8 family] (according to UniProt)
[wiki|Domains]
[wiki|peptidase S8 domain] (aa 422-729) (according to UniProt)
Structure
[PDB|1DBI] (the peptidase S8 domain from Bacillus sp., aa 458 ... 687, 46% identity) [pubmed|10588904]
[AF|P54423]
[wiki|Localization]
extracellular (signal peptide) [Pubmed|18957862]
membrane [Pubmed|18763711]
cell wall [Pubmed|23180473]
Expression and Regulation
Operons
genes
[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]
description
[Pubmed|16306698]
regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|22900538]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|22900538], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb]: activation, [Pubmed|16306698], in [regulon|protein:7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22900538], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
An [wiki|ncRNA] is predicted for'[protein|search|wprA]' [PubMed|20525796]
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[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]

2024-10-05 17:48:09

ghost

64

e443acbf9edef1d3c45668d5be2f5928e483f55a

C9994F3944A197640761292D0407814113E22072

Biological materials
Mutant
1A1021 ( ''wprA''::''kan''), [Pubmed|20400548], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1021&Search=1A1021 BGSC]
BKE10770 (Δ[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTATCCCTCCTGCAAA,  downstream forward: _UP4_TAACCAAAAAGCGGTGCTCG
BKK10770 (Δ[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTATCCCTCCTGCAAA,  downstream forward: _UP4_TAACCAAAAAGCGGTGCTCG
References
Reviews
25212246,34410368
Original Publications
22900538,22923395,23180473,21815947,10075409,11987133,9004506,20525796,18957862,18763711,16306698,9687444,12028417,24362423,24115457,10588904,38922753

DC0FDCA3FA6742B023E6877CE9554AA1D47012BB

Page visits: 5448

Time of last update: 2024-10-09 05:18:55

Author of last update: Jstuelk