csaA
168
molecular chaperone involved in protein secretion
locus
BSU_19040
Molecular weight
11.77 kDa
pI
8.69
function
protein secretion
product
molecular chaperone
essential
no
synonyms
csaA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0073 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,079,214 → 2,079,546
Phenotypes of a mutant
From unsuccessful trials to knock out the gene it was concluded that ''csaA'' apparently is essential. However, in a conditional mutant (Pspac-''csaA''), depletion of the gene product is not lethal. But secretion of some proteins including [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|sdpC] was reported to be affected unter such conditions.[Pubmed|10816431]
The protein
Catalyzed reaction/ biological activity
Secretion associated chaperone. Assumed functional analogue of ''E. coli'' SecB
Protein family
FIG1 subfamily (according to Swiss-Prot)
[wiki|Domains]
[wiki|tRNA-binding domain] (aa 6-110) (accordinig to UniProt)
Structure
[PDB|2NZO]
[AF|P37584]
[wiki|Localization]
cytoplasm [pubmed|10816431]
Additional information
The functional entity of CsaA is the homodimer [pubmed|17372352]
Expression and Regulation
Operons
genes
[gene|EDD0C5732E487A7F94684289F59B9130773316C1|yobT]-[gene|BB122C73972ACEA08DE97F95FC9AC249671C86A3|yobS]-[gene|6D9AAA63C4E43D2F80C7A2104BDF4D98A21C3B78|yobR]-[gene|6C67AD722D59671ED7589949690773732A8B845F|yobQ]-[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]
description
[pubmed|22383849]
genes
[gene|6D9AAA63C4E43D2F80C7A2104BDF4D98A21C3B78|yobR]-[gene|6C67AD722D59671ED7589949690773732A8B845F|yobQ]-[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]
description
[pubmed|22383849]
Biological materials
Mutant
Pspac-csaA [Pubmed|10816431]
BKE19040 (Δ[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE19040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAATAACTCCTTTTT, downstream forward: _UP4_TAACGCAAAAAAAGACGTTT
BKK19040 (Δ[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK19040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAATAACTCCTTTTT, downstream forward: _UP4_TAACGCAAAAAAAGACGTTT
References
Reviews
Original Publications
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Time of last update: 2024-10-14 14:24:30
Author of last update: Melvin.boenninger