hxlR
168
[wiki|MarR family|MarR/DUF24 family] transcription activator of the [gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]-[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB] operon
locus
BSU_03470
Molecular weight
14.01 kDa
pI
6.36
function
regulation of the ribulose monophosphate pathway
product
[wiki|MarR family|MarR/DUF24 family] transcription activator
essential
no
synonyms
hxlR, yckH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1733 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
376,032 → 376,394
The protein
Catalyzed reaction/ biological activity
transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
Protein family
[wiki|MarR family|MarR/DUF24 family]
[wiki|Domains]
[wiki|HTH hxlR-type domain] (aa 11-110) (according to UniProt)
Structure
[PDB|7BZD] [pubmed|33495458]
[AF|P42406]
Effectors of protein activity
formaldehyde stimulates transcription activation by HxlR [pubmed|33495458]
Paralogous protein(s)
[protein|E757C4B329A99E3D0C70C77437DF4DDA300CA5E7|ydzF], [protein|91085DA5E71B88E533D2E1D1BFB53E908116C6AA|hypR], [protein|51B1913B59C1876CCED4A88414797B3A22BE4E3C|ydeP], [protein|1E74F0557FF9ECB404B6544831F4E0A162473423|ytcD], [protein|C57DDC9710CB557179B062F9C5D786DB02A3B5FC|ykvN], [protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]
Expression and Regulation
Operons
genes
[gene|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR]
description
[Pubmed|22383849]
additional information
A [wiki|search|ncRNA] is predicted between [gene|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR] and [gene|81845F44CE2C601555066E31E87384FF5D7B4139|srfAA] [PubMed|20525796]
Biological materials
Mutant
BKE03470 (Δ[gene|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAGAATCCCCCCCCTTA, downstream forward: _UP4_TAAGACGCTCTTCGCAAGGG
BKK03470 (Δ[gene|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03470 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATAGAATCCCCCCCCTTA, downstream forward: _UP4_TAAGACGCTCTTCGCAAGGG
References
Page visits: 5920
Time of last update: 2024-12-22 08:43:32
Author of last update: Jstuelk