dck
168
deoxyadenosin/deoxycytidine kinase
locus
BSU_00140
Molecular weight
25.30 kDa
pI
5.54
function
purine salvage and interconversion
product
deoxyadenosin/deoxycytidine kinase
essential
no
synonyms
dck, yaaF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1428 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
22,496 → 23,149
The protein
Catalyzed reaction/ biological activity
ATP + deoxyadenosine --> ADP + dAMP (accoding to UniProt)
NTP + deoxycytidine --> NDP + dCMP (accoding to UniProt)
Protein family
DCK/DGK family (together woth [protein|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]) (accoding to UniProt)
Structure
[PDB|8PUU] (from Giardia intestinalis , 39.8% identity)
[AF|P37529]
Paralogous protein(s)
[protein|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]
[wiki|Localization]
cytoplasm (accoding to UniProt)
Expression and Regulation
Operons
genes
[gene|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]-[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-B887 (yaaF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1886 NBRP B. subtilis, Japan]
BKE00140 (Δ[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTCTTAGGGATATGATGTT, downstream forward: _UP4_TGAATCTCAGTCGAGATTCA
BKK00140 (Δ[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTCTTAGGGATATGATGTT, downstream forward: _UP4_TGAATCTCAGTCGAGATTCA
References
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Time of last update: 2025-01-12 07:14:40
Author of last update: Jstuelk