yabM
168
may function in a previously observed alternate pathway for peptidoglycan strand synthesis
locus
BSU_00570
Molecular weight
57.19 kDa
pI
9.62
function
alternate pathway for peptidoglycan strand synthesis
product
unknown
essential
no
synonyms
yabM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5841 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
64,817 → 66,415
Phenotypes of a mutant
mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A [wiki|penicillin-binding proteins] [Pubmed|19648239]
inactivation suppresses the essentiality of [gene|6ED386D49F973C1F6B1076974F54275DD583C9D3|mbl] [pubmed|39185233]
The protein
Catalyzed reaction/ biological activity
may function in a previously observed alternate pathway for peptidoglycan strand synthesis [Pubmed|19648239]
Protein family
[wiki|Polysaccharide synthase family] (according to UniProt)
[wiki|MOP exporter family]
Structure
[AF|P37555]
Paralogous protein(s)
[protein|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|murJ], [protein|34A5CD28A3DBCB10B4E1C82E50143FA73B553919|ykvU], [protein|9633C40190B7D0EA264270FD44567C61A012AD15|spoVB]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]-[gene|52D48F22CB53421EE30970D34B4861E2F8A5893D|yabN]-[gene|B0CB19A3E3E84E12BF42BB050394C8A059A89359|rqcP]-[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
regulation
expressed during sporulation ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|11283287]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,11283287], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|12207695], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|26577401], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
[protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX]: sigma factor, [Pubmed|12207695], in [regulon|protein:E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX regulon]
Biological materials
Mutant
MGNA-B914 (yabM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1913 NBRP B. subtilis, Japan]
BKE00570 (Δ[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA, downstream forward: _UP4_AAATTCATGAGAAGGAGAGA
BKK00570 (Δ[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA, downstream forward: _UP4_AAATTCATGAGAAGGAGAGA
References
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Time of last update: 2024-12-30 10:28:14
Author of last update: Jstuelk