capC

capC
168

part of the [protein|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[protein|D66994D077D1382B88FF65075E44C2A31089548F|capC] glutamic acid ligase, capsular polyglutamate biosynthesis

locus
BSU_35890
Molecular weight
16.16 kDa
pI
9.67
Protein length
149 aaSequenceBlast
Gene length
450 bpSequenceBlast
function
capsule synthesis
product
unknown
essential
no
synonyms
capC, ywtA, pgsC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,698,982 → 3,699,431
Phenotypes of a mutant
no synthesis of the poly-gamma-glutamate capsule [Pubmed|11751809]
The protein
Structure
[AF|P96737]
Expression and Regulation
Operons
genes
[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]
description
[Pubmed|11751809]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|19734658], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|19420703], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
expression of the operon is increased in '[protein|search|motA]' or '[protein|search|motB]' mutants due to increased [protein|search|DegU] phosphorylation [PubMed|24296669]
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[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]→[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]

2024-11-01 13:00:49

ghost

99

bf6b0bf03353d832d0fb99e09c0c2fcd8af8f057

1302D3190C59C849B9803B3A11C008FA08B67E54

Biological materials
Mutant
MGNA-A076 (ywtA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/76 NBRP B. subtilis, Japan]
BKE35890 (Δ[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35890 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TCCGAACATGTCTGCATTTC,  downstream forward: _UP4_ATTTAATGTAAGGTGTGTCA
BKK35890 (Δ[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35890 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TCCGAACATGTCTGCATTTC,  downstream forward: _UP4_ATTTAATGTAAGGTGTGTCA
References
Reviews
20735481,16689787,29215550
Original Publications
36815589,11751809,19420703,16233197,20564357,20564574,24296669,21965392,27073802,29971620,30295732,31837088,16278834

D66994D077D1382B88FF65075E44C2A31089548F

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Time of last update: 2024-12-24 00:44:13

Author of last update: Jstuelk