yidC1
168
Sec-independent membrane protein translocase, essential for [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG] activity at stage III, involved in the assembly of the [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH]-[protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ] complex
locus
BSU_41040
Molecular weight
29.37 kDa
pI
9.99
function
membrane insertion of proteins and [wiki|protein secretion]
product
membrane protein translocase
essential
no
synonyms
yidC1, spoIIIJ, undefined, spo0J87
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0706 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,213,823 → 4,214,608
Phenotypes of a mutant
defective in sporulation [pubmed|1487728]
additional information
a [protein|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1] gain-of-function mutation (Q140K) is present in B. subtilis strain PY97 [pubmed|31626625]
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The protein
Catalyzed reaction/ biological activity
membrane protein translocase, facilitates insertion of [protein|9D4AE9AE191BFA82791549852782DC1B959A6897|spoIIIAE] into the membrane [Pubmed|18485064]
Protein family
OXA1/ALB3/YidC family (with [protein|121A9543F5BC1CBE77D85A34099DE09F8AC63E9F|yidC2], according to UniProt) [Pubmed|20800571,21194367,15802250]
Structure
[PDB|3WO6] (from ''Bacillus halodurans'', 51% identity) [Pubmed|24739968]
[AF|Q01625]
Paralogous protein(s)
[protein|121A9543F5BC1CBE77D85A34099DE09F8AC63E9F|yidC2], one of the two proteins has to be present for viability [Pubmed|17114254]
[wiki|Localization]
membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|EB07AECD3849CC0B65126DE27E71B28B3AD106B0|rpmH]-[gene|594F2D36BE71A45303A33AA2A2931F56F0A969ED|rnpA]-[gene|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1]-[gene|23D33E2D7AB1CA02165070DB8238957E3C768E64|jag]
description
[Pubmed|22383849]
regulation
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
genes
[gene|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1]-[gene|23D33E2D7AB1CA02165070DB8238957E3C768E64|jag]
description
[Pubmed|1487728]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1487728], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
An antisense RNA is predicted for '[protein|search|jag]' [PubMed|20525796]
Biological materials
Mutant
BKE41040 (Δ[gene|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE41040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTCCTATAATTAAT, downstream forward: _UP4_AAGTGAGGAATGTGACTGCT
BKK41040 (Δ[gene|D40C202E67A5319A91811DB11356F47A56C97DD2|yidC1]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK41040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTCCTATAATTAAT, downstream forward: _UP4_AAGTGAGGAATGTGACTGCT
labs
[wiki|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ homepage]
[wiki|Adriano Henriques], Lisbon, Portugal [http://www.itqb.unl.pt/research/biology/microbial-development homepage]
References
Reviews
Original Publications
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Time of last update: 2024-09-09 21:41:35
Author of last update: Jstuelk