natR
168
two-component response regulator, regulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|A8ADA02BBB549866DE330040CF6D06ECC3B00099|natB] operon
locus
BSU_02740
Molecular weight
26.82 kDa
pI
6.61
function
regulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|A8ADA02BBB549866DE330040CF6D06ECC3B00099|natB] operon
product
two-component response regulator
essential
no
synonyms
natR, yccH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3279 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
295,584 → 296,285
The protein
Protein family
OmpR family of two-component response regulators
[wiki|Domains]
[wiki|Response regulatory domain] (aa 3-117) (according to UniProt)
HTH LytTR-type domain (aa 129-233) (according to UniProt)
Structure
[PDB|5HEV] (from Enterococcus faecium, corresponds to aa 1 ... 172, 22.3% identity) [pubmed|27670715]
[AF|P70955]
Modification
phosphorylated by [protein|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]-[gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-C043 (yccH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2041 NBRP B. subtilis, Japan]
BKE02740 (Δ[gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATCATTCCCCTAGTTA, downstream forward: _UP4_TACTATTTTTGAGGAGTTTA
BKK02740 (Δ[gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATCATTCCCCTAGTTA, downstream forward: _UP4_TACTATTTTTGAGGAGTTTA
References
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Time of last update: 2024-12-31 03:08:44
Author of last update: Christoph.elfmann