tseB
168
cell shape control via [protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A], required for efficient cell wall elongation during exponential phase and spore outgrowth, tetracycline sensitivity suppressor of [gene|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|ezrA]
locus
BSU_22380
Molecular weight
17.75 kDa
pI
9.24
function
control of [protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A]
product
regulator of [protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A]
essential
no
synonyms
tseB, ypmB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5353 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,348,864 → 2,349,349
Phenotypes of a mutant
resistant to moenomycin [pubmed|29995990]
shorter and wider than wild type cells [pubmed|34411374]
[protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A] over expression is toxic in the mutant [pubmed|34411374]
inactivation suppresses the essentiality of [gene|6ED386D49F973C1F6B1076974F54275DD583C9D3|mbl] [pubmed|39185233]
The protein
Structure
[PDB|2GU3]
[AF|P54396]
[wiki|Localization]
cell membrane(according to UniProt)
Expression and Regulation
Operons
genes
[gene|A0001681244113B808757281C1B70C0C94F28A27|panB]-[gene|8BE55434677F4EC3D6766C7163496CB1B659F57F|panC]-[gene|EE712C1EC9E9C371847C83F7D75C189B276CD4B6|panD]-[gene|03BFD8AD2E3D95858752F46366F6C2028D709029|dinG]-[gene|08F907C6F47BDEB4DC9A9F136CDC6A4063AC0140|ypmA]-[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]-[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
description
[Pubmed|22383849]
genes
[gene|08F907C6F47BDEB4DC9A9F136CDC6A4063AC0140|ypmA]-[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]-[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
description
[Pubmed|29995990,22383849]
genes
[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]-[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
description
[Pubmed|22383849]
regulation
constitutive
Biological materials
Mutant
MGNA-A441 (ypmB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/441 NBRP B. subtilis, Japan]
BKE22380 (Δ[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCTTTTTTTCTCATCTTCT, downstream forward: _UP4_TAAGACGAATTAGGGGGAGT
BKK22380 (Δ[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCTTTTTTTCTCATCTTCT, downstream forward: _UP4_TAAGACGAATTAGGGGGAGT
References
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Time of last update: 2024-10-06 18:11:43
Author of last update: Jstuelk