tseB

tseB
168

cell shape control via [protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A], required for efficient cell wall elongation during exponential phase and spore outgrowth, tetracycline sensitivity suppressor of [gene|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|ezrA]

locus
BSU_22380
Molecular weight
17.75 kDa
pI
9.24
Protein length
Gene length
function
control of [protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A]
product
regulator of [protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A]
essential
no
synonyms
tseB, ypmB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5353 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,348,864 → 2,349,349
Phenotypes of a mutant
resistant to moenomycin [pubmed|29995990]
shorter and wider than wild type cells [pubmed|34411374]
[protein|3B4F035535D6504405567E7C44E72902A11F7447|PBP 2A] over expression is toxic in the mutant [pubmed|34411374]
inactivation suppresses the essentiality of [gene|6ED386D49F973C1F6B1076974F54275DD583C9D3|mbl] [pubmed|39185233]
The protein
Structure
[PDB|2GU3]
[AF|P54396]
[wiki|Localization]
cell membrane(according to UniProt)
Expression and Regulation
Operons
genes
[gene|A0001681244113B808757281C1B70C0C94F28A27|panB]-[gene|8BE55434677F4EC3D6766C7163496CB1B659F57F|panC]-[gene|EE712C1EC9E9C371847C83F7D75C189B276CD4B6|panD]-[gene|03BFD8AD2E3D95858752F46366F6C2028D709029|dinG]-[gene|08F907C6F47BDEB4DC9A9F136CDC6A4063AC0140|ypmA]-[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]-[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
description
[Pubmed|22383849]
Open in new tab

[gene|A0001681244113B808757281C1B70C0C94F28A27|panB]→[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]

2024-12-21 13:41:38

Jstuelk

62

3C14CF916926052D4B293230C8985ACC791FC72B

3C14CF916926052D4B293230C8985ACC791FC72B

genes
[gene|08F907C6F47BDEB4DC9A9F136CDC6A4063AC0140|ypmA]-[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]-[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
description
[Pubmed|29995990,22383849]
Open in new tab

[gene|search|ympA]→[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]

2024-12-21 14:07:25

Jstuelk

67

1da6fe75124a7fb6321a113190f25efae7809829

46F8DB4DFCCA60148B66F350A7F182AB4E0080EE

genes
[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]-[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]
description
[Pubmed|22383849]
regulation
constitutive
Open in new tab

[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]→[gene|AE802E1D4F827DED3A5D953C7D034E6A3554C45F|aspB]

2024-12-21 13:55:43

ghost

83

853e576eeb824705f6265e3321731a7e0894baa0

509E8FD6169FFC3F028F50E50BD5DF60375119E6

Biological materials
Mutant
MGNA-A441 (ypmB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/441 NBRP B. subtilis, Japan]
BKE22380 (Δ[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22380 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCTTTTTTTCTCATCTTCT,  downstream forward: _UP4_TAAGACGAATTAGGGGGAGT
BKK22380 (Δ[gene|D3629004F3B54D11566AE15227174F9EB7784201|tseB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22380 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCTTTTTTTCTCATCTTCT,  downstream forward: _UP4_TAAGACGAATTAGGGGGAGT
References
36815589,25954268,29995990,34411374

D3629004F3B54D11566AE15227174F9EB7784201

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Time of last update: 2024-12-21 03:36:24

Author of last update: Jstuelk