pdp
168
pyrimidine nucleoside phosphorylase
locus
BSU_39400
Molecular weight
46.04 kDa
pI
4.76
function
pyrimidine interconversion
product
pyrimidine nucleoside phosphorylase
essential
no
ec
2.4.2.2
synonyms
pdp
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0213 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,049,009 → 4,050,310
The protein
Catalyzed reaction/ biological activity
phosphate + uridine --> α-D-ribose 1-phosphate + uracil (according to UniProt)
phosphate + thymidine --> 2-deoxy-α-D-ribose 1-phosphate + thymine (according to UniProt)
2'-deoxyuridine + phosphate --> 2-deoxy-α-D-ribose 1-phosphate + uracil (according to UniProt)
Protein family
thymidine/pyrimidine-nucleoside phosphorylase family (single member, according to UniProt)
Structure
[PDB|5OLN] [PubMed|29633966]
[AF|P39142]
Expression and Regulation
Operons
genes
[gene|81CD1F97E887549F7FB742FCEF38B86B84383F5D|dra]-[gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]-[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp]
description
[Pubmed|8550462]
regulation
induced by deoxynucleotides ([protein|search|DeoR]) [Pubmed|8550462]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]: repression, [Pubmed|8550462], in [regulon|protein:E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550462], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
Biological materials
Mutant
BKE39400 (Δ[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTGGTCACCGATCCT, downstream forward: _UP4_TAAAAAATAAAGCACATCCC
BKK39400 (Δ[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTGGTCACCGATCCT, downstream forward: _UP4_TAAAAAATAAAGCACATCCC
References
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Time of last update: 2024-12-26 05:20:22
Author of last update: Melvin.boenninger