gerKB
168
nutrient receptor
locus
BSU_03720
Molecular weight
41.61 kDa
pI
8.92
function
germination
product
part of the putative nutrient-gated [protein|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[protein|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]-[protein|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC] ion channel
essential
no
synonyms
gerKB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5902 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
422,982 → 424,103
The protein
Catalyzed reaction/ biological activity
the [protein|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[protein|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]-[protein|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC] ion channel likely releases ions from the spore core in response to asparagine, glucose, fructose and K+ to trigger [category|SW.4.2.4|Germination], this requires the gerB locus [pubmed|37104613]
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
[wiki|Spore germination protein (SGP) (TC 2.A.3.9) family] (according to UniProt)
Structure
[AF|P49940]
Paralogous protein(s)
[protein|D70EC7C02BC79BED724489ABCB6356447F215B87|gerBB], [protein|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB], [protein|B14179D0EF5D3493E5CDB8E15378A5088B4FFD10|yndE]
[wiki|Localization]
spore inner membrane [Pubmed|21696470]
Expression and Regulation
Operons
genes
[gene|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[gene|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC]-[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]
description
[pubmed|22383849]
regulation
expressed during sporulation ([protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG], [wiki|SpoVT]) [Pubmed|16707705]
regulatory mechanism
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT]: repression, [Pubmed|16707705], in [regulon|protein:01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT regulon]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|16707705], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
additional information
700 molecules are present per spore [PubMed|23749970]
Biological materials
Mutant
BKE03720 (Δ[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCACTTCCCCTTTC, downstream forward: _UP4_TGATAAAAAGAGCGGGGGGA
BKK03720 (Δ[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCACTTCCCCTTTC, downstream forward: _UP4_TGATAAAAAGAGCGGGGGGA
References
Page visits: 3751
Time of last update: 2024-12-21 15:00:45
Author of last update: Jstuelk