ahpC
168
alkyl hydroperoxide reductase (small subunit)
locus
BSU_40090
Molecular weight
20.48 kDa
pI
4.28
function
resistance against peroxide stres
product
alkyl hydroperoxide reductase (small subunit)
essential
no
ec
1.11.1.15
synonyms
ahpC, perR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0450 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,118,950 4,119,513
The protein
Catalyzed reaction/ biological activity
[protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H2O (according to UniProt)
Protein family
[wiki|peroxiredoxin family] (according to UniProt)
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 2-157) (according to UniProt)
Structure
[PDB|1WE0] (from ''Amphibacillus xylanus'', 78% identity, 88% similarity) [Pubmed|15770647]
[AF|P80239]
Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
CoA is attached to Cys-166 in spores [pubmed|33206970]
Paralogous protein(s)
[protein|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|D0982500E52577D52FADF775C0E512A4B9657B79|ahpC]-[gene|8F23B575BC32EA63267C4321DD8E4BD546B11AF1|ahpF]
description
[Pubmed|8932314]
regulation
induced by H2O2 ([protein|search|PerR]) [Pubmed|11532148]
regulatory mechanism
[protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR]: repression, [Pubmed|11532148], in [regulon|protein:00BCAAE16576DC5426A652580C69A570FC7A1C2C|perR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8932314], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
GP1730 [gene|search|ahpCF]::mls trpC2 available at Jrg Stlkes lab
BKE40090 ([gene|D0982500E52577D52FADF775C0E512A4B9657B79|ahpC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40090 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATGTATATTCCTCCTA, downstream forward: _UP4_GGTAAAATCTAAGGAGTGCA
BKK40090 ([gene|D0982500E52577D52FADF775C0E512A4B9657B79|ahpC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40090 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATGTATATTCCTCCTA, downstream forward: _UP4_GGTAAAATCTAAGGAGTGCA
References
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Time of last update: 2024-12-31 09:37:12
Author of last update: Jstuelk