azoR1

azoR1
168

azoreductase, involved in quinone detoxification

locus
BSU_19230
Molecular weight
22.83 kDa
pI
4.99
Protein length
Gene length
function
quinone detoxification
product
azoreductase
essential
no
synonyms
azoR1, yocJ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1182 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,096,350 2,096,976
The protein
Catalyzed reaction/ biological activity
anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD+ --> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H+ + 2 NADH (according to UniProt)
Protein family
azoreductase type 1 family (with [protein|0E2B1914A040666BAF042C0BE3F468144E1F1E06|azoR2], according to UniProt)
Structure
[PDB|3P0R] (from B. anthracis, 64% identity, 81% similarity)
[AF|O35022]
Paralogous protein(s)
[protein|0E2B1914A040666BAF042C0BE3F468144E1F1E06|azoR2]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|CFFFFE96FB7AEEF7190F81332369F0A6834C34A4|azoR1]
description
[pubmed|22383849]
regulation
induced by thiol-reactive compounds (catechol, menaquinone) ([protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]) [pubmed|18208493]
regulatory mechanism
[protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]: repression, [pubmed|18208493], in [regulon|protein:73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB regulon]
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[gene|CFFFFE96FB7AEEF7190F81332369F0A6834C34A4|azoR1]

2024-09-28 03:08:18

Bzhu

80

3010a253791488a0c14278049a20c80502f26844

8881E3C43D39AF052197A1E21C2D9298F5FD8D97

Biological materials
Mutant
MGNA-B415 (yocJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1414 NBRP B. subtilis, Japan]
BKE19230 ([gene|CFFFFE96FB7AEEF7190F81332369F0A6834C34A4|azoR1]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE19230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGTATTCCTCCCGGTA, downstream forward: _UP4_TAATAAAGCCAAGACTCCTA
BKK19230 ([gene|CFFFFE96FB7AEEF7190F81332369F0A6834C34A4|azoR1]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK19230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGTATTCCTCCCGGTA, downstream forward: _UP4_TAATAAAGCCAAGACTCCTA
References
18208493,17725564,15378759

CFFFFE96FB7AEEF7190F81332369F0A6834C34A4

Page visits: 2837

Time of last update: 2024-10-09 01:45:33

Author of last update: Melvin.boenninger