ispD

ispD
168

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, third step in the MEP pathway of isoprenoid biosynthesis

Locus
BSU_00900
Molecular weight
25.70 kDa
Isoelectric point
5.58
Protein length
232 aaSequenceBlast
Gene length
699 bpSequenceBlast
Function
MEP pathway of isoprenoid biosynthesis
Product
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Essential
yes
E.C.
2.7.7.60
Synonyms
ispD, yacM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1211 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
109,789 → 110,487
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
2-C-methyl-D-erythritol 4-phosphate + CTP + H+ --> 4-CDP-2-C-methyl-D-erythritol + diphosphate (according to UniProt)
Protein family
cytidylyltransferase family (with TagD and YfnH, according to UniProt)
IspD/TarI cytidylyltransferase family (single member, according to UniProt)
Structure
5DDT (PDB) PubMed
5DDV (PDB) PubMed
Q06755 (AlphaFold)
Expression and Regulation
Operons
Genes
yacL-ispD-ispF
Description
PubMed
Regulation
induced by stress (SigB) PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
SigM: sigma factor, PubMed, in sigM regulon
Open in new tab

yacL→ispF

2025-04-04 00:34:02

ghost

91

7dc686870ed58f71ca9e5b0841c69a922f74d84a

EFDC5F8C8F63B342C29A9AB39CD8005147D16917

Biological materials
Mutant
MGNA-B881 (yacM::erm), available at the NBRP B. subtilis, Japan
References
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CF9633F769263C6D16EE778F6BD2ECF1995F512A

Page visits: 5571

Time of last update: 2025-04-07 16:00:43

Author of last update: Melvin.boenninger