pyrG

pyrG
168

CTP synthase (NH3, glutamine)

locus
BSU_37150
Molecular weight
59.55 kDa
pI
5.16
Protein length
Gene length
function
pyrimidine biosynthesis
product
CTP synthase (NH3, glutamine)
essential
yes
ec
6.3.4.2
synonyms
pyrG, ctrA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0504 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,810,693 → 3,812,300
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
ATP + H2O + L-glutamine + UTP --> ADP + CTP + 2 H+ + L-glutamate + phosphate (according to UniProt)
Protein family
CTP synthase family (single member, according to UniProt)
[wiki|Domains]
[wiki|Glutamine amidotransferase type-1 domain] (aa 292-534) (according to UniProt)
Structure
[PDB|1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) [Pubmed|15296735]
[AF|P13242]
Expression and Regulation
Operons
genes
[gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]-[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]
description
[Pubmed|29794222]
regulation
the mRNA is processed between [gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE] and [gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
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[gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]→[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]

2024-07-13 06:53:35

Jstuelk

90

6981b09ca9032cfc7bc05bc8cdc4cd3f50e72d60

287D78850C93C76A33BB00CF472FBB12D1359561

genes
[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]
description
[Pubmed|2457578]
regulation
repressed by cytidine nucleotides ([wiki|RNA switch]) [Pubmed|11544212]
regulatory mechanism
RNA switch: RNA switch, in [regulon|other_regulator:RNA switch|RNA switch]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|15252202], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]

2024-07-13 03:41:44

ghost

42

9532ea11ebb067554578afd02feb3d4277a91a3e

7D87DAF140838B99ACFC58C27C969673BACCEF98

additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
References
Reviews
21334966,18535147
Original Publications
8206849,17302819,15252202,11544212,1709162,12426364,17158658,2457578,28652344,26883633,29794222,31965171,32973723

CEE04B9FED63AFEAB912791402F7578E852005D1

Page visits: 4700

Time of last update: 2024-07-14 23:53:02

Author of last update: Jstuelk