pyrG
168
CTP synthase (NH3, glutamine)
locus
BSU_37150
Molecular weight
59.55 kDa
pI
5.16
function
pyrimidine biosynthesis
product
CTP synthase (NH3, glutamine)
essential
yes
ec
6.3.4.2
synonyms
pyrG, ctrA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0504 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,810,693 → 3,812,300
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + H2O + L-glutamine + UTP --> ADP + CTP + 2 H+ + L-glutamate + phosphate (according to UniProt)
Protein family
CTP synthase family (single member, according to UniProt)
[wiki|Domains]
[wiki|Glutamine amidotransferase type-1 domain] (aa 292-534) (according to UniProt)
Structure
[PDB|1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) [Pubmed|15296735]
[AF|P13242]
Expression and Regulation
Operons
genes
[gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]-[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]
description
[Pubmed|29794222]
regulation
the mRNA is processed between [gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE] and [gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
genes
[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]
description
[Pubmed|2457578]
regulation
repressed by cytidine nucleotides ([wiki|RNA switch]) [Pubmed|11544212]
regulatory mechanism
RNA switch: RNA switch, in [regulon|other_regulator:RNA switch|RNA switch]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|15252202], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
References
Reviews
Original Publications
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Time of last update: 2025-04-17 12:42:06
Author of last update: Jstuelk