bsuMB

bsuMB
168

DNA-3-methyladenine glycosidase II

Locus
BSU_06070
Molecular weight
43.12 kDa
Isoelectric point
6.43
Protein length
389 aaSequenceBlast
Gene length
1170 bpSequenceBlast
Function
BsuM DNA modification
Product
DNA-3-methyladenine glycosidase
Essential
yes
Synonyms
ydiP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0270 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
656,528 → 657,697
Phenotypes of a mutant
essential PubMed, mutation is only possible in a ''bsuRA, bsuRB, or bsuRC background (i. e.'', in the absence of the BsuM DNA restriction system) PubMed
The protein
Catalyzed reaction/ biological activity
2'-deoxycytidine in DNA + S-adenosyl-L-methionine --> 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine
Protein family
Methyltransferase superfamily (according to UniProt)
class I-like SAM-binding methyltransferase superfamily (according to UniProt)
Domains
SAM-dependent MTase C5-type domain (aa 1-299) (according to UniProt)
Structure
1DCT (PDB) (from Haemophilus aegyptus, 26% identity) PubMed
O34680 (AlphaFold)
Expression and Regulation
Operons
Genes
bsuMA-bsuMB
Description
PubMed
Regulation
induced by DNA damage (LexA) PubMed
Regulatory mechanism
LexA: repression, PubMed, in lexA regulon
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bsuMA→bsuMB

2025-03-13 11:03:49

ghost

83

02fb4b87b42edce33e5de630e0a1a94c510aedf2

2DB1B41F609EEBE1AAC90B8FBC791043330EB836

References
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CEA337DD4C7DFC22247FDA7FA1E71356FB819C77

Page visits: 3657

Time of last update: 2025-04-27 23:44:11

Author of last update: Jstuelk